Speaker Nancy Pelosi canceled a vote on President Joe Biden's infrastructure bill late Thursday, putting a key portion of his flagship domestic agenda in jeopardy amid a fractious Democratic Party.

On Friday, Democrats intend to continue their efforts.

Pelosi, D-Calif., told centrist Democrats that the House would vote on the infrastructure proposal on Thursday regardless of whether work on the second, larger part of Biden's agenda, a multibillion-dollar expansion of the nation's social safety net programs, was completed.

She worked nonstop all day to win votes for the $1 trillion infrastructure package and a framework agreement on the size and scope of the safety-net bill. Susan Rice, a White House domestic policy adviser, and Brian Deese, a White House national economic adviser, visited Capitol Hill to assist in the negotiations between Democratic leaders and two moderate Democratic Senate holdouts. However, at around 10 p.m., those attempts came to a stop.

Pelosi's track record of closely managing House Democrats was tested by progressives in her caucus' extraordinary willingness to temporarily reject the infrastructure measure in order to assure the party lands a bigger fish: social spending and climate legislation.

Biden's "Build Back Better" agenda includes both bills.

Democrats indicated as early as Thursday afternoon that canceling the vote would not be a final setback and that all parties would continue to work together. Some even saw Thursday's events as a sign of progress, as moderate holdout Sen. Joe Manchin III of West Virginia revealed his top-line figure after months of secrecy.

However, the cancellation indicates that significant movement on either bill is still weeks, if not months, away.

“This whole agenda that President Biden has put forth is hanging in the balance,” said Rep. Barbara Lee, D-Calif.

Furthermore, moderates are likely to see the postponed vote as a breach of trust. Rep. Stephanie Murphy, D-Fla., the leader of a group of centrist Democrats, warned earlier this week that doing so would be a "breach of trust."

Meanwhile, lawmakers checked one item off their to-do list on Thursday when they voted to keep the government funded only hours before it ran out of money. They have failed to confront a looming fiscal crisis: increasing the debt ceiling to avoid a government default in two weeks.

Pelosi met with a number of groups of members on Thursday in an attempt to reach an agreement on a number of subjects, including health care, climate change, and the child tax credit.

According to one moderate Democrat who spoke on the condition of anonymity about internal negotiations, “she's been aggressively negotiating details of the (safety net bill) to try to close as many of those issues as possible so that the progressives will feel more comfortable voting” on infrastructure.

Pelosi described the social spending bill, which is expected to include a child tax credit and prekindergarten and child care subsidies, as "the culmination of (her) service in Congress because it (is) about the children," a remark that is likely to fuel speculation on Capitol Hill that the bill will be the speaker's final major piece of legislation. She announced in 2018 that she would resign as Speaker of the House by the end of 2022.

To approve the infrastructure bill, lawmakers will have to overcome a wide rift between House Democrats and Manchin, as well as fellow centrist Sen. Kyrsten Sinema of Arizona, who have stated that a $3.5-trillion price tag on the social safety net measure will not be supported.

Rep. Ro Khanna, D-Calif., tweeted, "This isn't progressives vs. moderates." “It's the Democratic Party as a whole and Joe Biden versus Kyrsten Sinema.”

Despite weeks of debate, it was unclear exactly what Manchin and Sinema wanted until Thursday.

For the first time, Manchin stated publicly that he would back a $1.5 trillion safety net package, which is roughly half of what other Democrats have agreed to and an ominous indication for those hoping to win his support.

Manchin and Majority Leader Charles E. Schumer, D-N.Y., reached an agreement in July declaring that he would support a top line of $1.5 trillion. Members of Manchin's party were relieved when the document was made public because they finally knew where he stood.

However, it sparked questions about why his viewpoint was kept hidden for so long as most Democrats rallied around the $3.5 trillion price tag.

Manchin responded to House Democrats who said he and Sinema were not bargaining in good faith, saying, "We only have 50 votes." “Take whatever we can't agree on today and take it to the campaign trail with you. With what they claim they want, I'm confident they'll get a lot more liberal, progressive Democrats.”

He stated that he opposes the creation of new government programs that provide benefits to all people regardless of their income level. In a statement, he said, “I cannot — and will not — support trillions in spending or an all-or-nothing approach that ignores the brutal fiscal reality our country faces.”

Sinema's office stated in a statement that she had privately engaged with Biden and congressional leaders about her "detailed concerns and priorities," and that she "does not negotiate through the press."

Democrats were bolstered by the prospect of a 50-50 split in the Senate.

Senate Majority Whip Richard J. Durbin, D-Ill., stated on CNN, "We can't delay these things." “Delaying them simply invites a bad outcome.... We're one heartbeat away from losing the Senate majority.”

It's unclear how Democrats would reduce the size of their social safety net package. They could eliminate entire programs or drastically reduce the number of years they are in existence by lowering the number of years they are in effect or limiting them depending on income.

According to some Democrats, an ambitious plan to require pharmaceutical corporations to negotiate prescription pricing in Medicare — a longtime Democratic campaign pledge that would free up hundreds of billions of dollars for other health-care programs — would likely be trimmed or scaled back.

The success of the party in the 2022 midterm election may be determined by whether or not they have followed through on their campaign pledges.

Rep. Tom Malinowski, D-N.J., said his people will be more concerned with what is contained in the end product than with short-term delays in Congress. He emphasized the importance of affordable child care and the restoration of state and local tax deductions, which were capped under Trump's presidency.

“I'm going to win reelection if we finish this process with those things,” he stated.