Thursday marked the first time in weeks that Russian missiles attacked the southern Odesa area and the city of Dnipro.
Across the nation, air raid sirens rang as officials feared another large-scale missile attack from Moscow.
Through a Telegram message, Odesa's governor Maksym Marchenko announced that an infrastructure goal had been met.
He also warned of the possibility of a "massive missile barrage on the all of Ukraine's land."
Multiple explosions were reported in Dnipro, where two infrastructure objects were damaged and at least one person was injured, according to Kyrylia Tymoshenko, the deputy head of the Ukrainian presidential office.
According to Oleksiy Kuleba, the governor of Kyiv, air defense systems were operational throughout the central region of Ukraine.
Officials in the areas of Poltava, Kharkiv, Khmelnytskyi, and Rivne also recommended citizens remain in bomb shelters due to the persistent threat of missile attacks.
The attacks on the Odesa region are a continuation of the massive barrage of Russian assaults on Tuesday, representing the largest attack on Ukraine's energy infrastructure yet.
A missile that fell within Poland's borders also resulted in the deaths of two individuals.
Initially, Russia was accused of launching the missile, but Poland has since stated that it was likely found by air defenses in Ukraine's neighboring territory.
As winter approaches and its fighting losses grow, Russia has increasingly turned to attack Ukraine's power grid.
The most recent onslaught followed days of elation in Ukraine, which was fueled by one of the country's most significant military victories: the recapture of the city of Kherson in the south.
In a Thursday Telegram message, the chief of the Ukrainian presidential office, Andriy Yermak, referred to the attacks on energy targets as "the stupid strategy of cowardly losers."
Mr. Yermak wrote, "Ukraine has already endured incredibly severe enemy attacks that did not provide the desired effects for the Russian cowards."