Spain and Brazil reported one monkeypox-related death, which is believed to be the first fatalities associated with an outbreak that began in early May.
According to the health ministry's emergency and alert coordination office, Spain is among the worst-affected nations, with 4,298 instances of the virus.
"Of the 3,750 (monkeypox) patients with available information, 120 were hospitalized (3.2%), and one patient died," the center reported in a Friday report.
A health ministry spokeswoman declined to provide any information about the deceased patient. An autopsy is scheduled to occur.
The deceased patient in Brazil was a 41-year-old guy.
According to the ministry of health, he also had lymphoma and a compromised immune system.
After being transferred to the intensive care unit and brought to a hospital in the southeastern city of Belo Horizonte, he succumbed to septic shock and passed away.
"It is essential to emphasize that he had significant co-morbidities to avoid spreading panic among the population. Fabio Baccheretti, the health secretary of Minas Gerais, stated that the mortality rate associated with monkeypox is extremely low.
Global health emergency
Nearly 1,000 cases of monkeypox have been reported by Brazil's health ministry, primarily in the states of Sao Paulo and Rio de Janeiro, which are both in the country's southeast. Along with the United States and Canada, it is one of the most affected countries in the Americas by monkeypox.
Early symptoms of the disease include a high fever, enlarged lymph nodes, and a rash resembling chickenpox.
The first case of the current outbreak was confirmed in the United Kingdom on May 7, and according to the World Health Organization (WHO), the emergence of hundreds of cases outside the central and western African nations where the virus is endemic suggests that it has been spreading for some time without detection.
The WHO declared the outbreak a global health emergency a week ago, after around 18,000 cases were discovered in 78 countries.
On Wednesday, Tedros Adhanom Ghebreyesus, the head of the World Health Organization, stated that about 70 percent of cases were detected in Europe and 25 percent in the Americas.
As the number of reported cases increases worldwide, the World Health Organization (WHO) urged males who have intercourse with other men to limit their sexual partners on Wednesday.
After two to three weeks, the condition often recovers independently, although recovery can occasionally take a month.
The Danish pharmaceutical company Bavarian Nordic's smallpox vaccine, sold under the brand names Jynneos in the United States and Imvanex in Europe, has been found to protect monkeypox.