The latest Spider-Man film has become the first pandemic-era film to gross more than $1 billion (£750 million) at the global box office.
Spider-Man: No Way Home also became the highest-grossing film of the year in 2021.
It triumphed over a Chinese-made Korean War epic. The Battle of Lake Changjin made over $905 million worldwide.
According to media data analytics firm Comscore, the most recent film to gross more than $1 billion was 2019's Star Wars: The Rise of Skywalker.
Since the pandemic began two years ago, no other Hollywood production has come close to surpassing that box office milestone.
Over the weekend, the latest Marvel Cinematic Universe picture grossed $1.05 billion at the global box office.
Sony and Disney's co-production reached the milestone less than two weeks after its premiere, although the Omicron variety of Covid-19 has spread swiftly worldwide, generating new concerns regarding indoor activities.
The film has not been distributed in China, the world's largest cinema market at the moment.
Tom Holland reprises his role as Peter Parker in Spider-Man: No Way Home, with Zendaya's MJ and Benedict Cumberbatch as Doctor Strange's wizard.
The franchise's offering for 2019 Far From Home was the first Spider-Man film to generate over $1 billion at the box office and is now the franchise's highest-grossing picture with $1.132 billion in global ticket sales, according to Comscore.
The latest film is a sequel to Far From Home, in which the villainous Mysterio revealed Parker's identity before his death.
The series results from a partnership between Disney's Marvel Studios and Sony.
In 2015, Disney, Marvel Studios, and Sony decided to share the cinematic rights to Spider-Man, resulting in the introduction and integration of a new rendition of the character into the Marvel Cinematic Universe.
Before No Way Home, MGM's most recent James Bond film, No Time to Die, grossed $774 million worldwide, making it the highest-grossing Hollywood film of both 2021 and the epidemic.
