According to his son, Willie Garson, who played talent agent Stanford Blatch in Sex and the City, died at the age of 57.
In the hit HBO series, he portrayed Carrie Bradshaw, played by Sarah Jessica Parker, as a close friend and confidante. He had been working on the spin-off series And Just Like That most recently.
In the TV series White Collar, Garson played conman Mozzie.
The cause of his death has yet to be revealed.
Garson Paszamant was born in New Jersey in 1964 and studied theatre at Yale School of Drama, where he got a master's degree in fine arts.
In the 1980s, he played minor roles in several popular television shows, including Cheers, Family Ties, and LA Law. He also appeared in popular 1990s shows like The X-Files, Boy Meets World, and Friends.
Sex and the City premiered in 1998, and Garson played Stanford Blatch throughout the seasons, a character he returned in the franchise's two films.
On Instagram, Mario Cantone, who played Anthony Marentino, Garson's on-screen partner in the series, wrote: "I'm heartbroken and overcome with sadness... The gods gave you to us as a gift."
Miranda Hobbes was played by Cynthia Nixon, who said: "We all adored him and relished the opportunity to work with him. On-screen and off, he was inexhaustibly amusing. He was a beacon of brightness, camaraderie, and showbiz knowledge."
Michael Patrick King, the executive producer of Sex And The City and Just Like That, said Garson had been working "even while he was sick" but did not elaborate.
In a statement, he added, "His spirit and his dedication to his craft was present every day," "His multitude of gifts as an actor and person will be missed by everyone."
Groundhog Day, There's Something About Mary, and Fever Pitch are among his film credits.
Garson was also a staunch supporter of adoption, having adopted his son Nathen in 2009, who paid tribute to him on Instagram.
"I'm so glad you got to share all your adventures with me and were able to accomplish so much," he remarked. "I'm incredibly proud of you. I will always adore you, but I believe it is time for you to embark on your own adventure."