The 36-year-old actress also stated that she would not fault the general people for viewing her multimillion-dollar legal action against her ex-husband and concluding that "this is Hollywood brats at their worst."
She told NBC Today's Savannah Guthrie that social media played a vital role in the case and was not a "fair representation."
When asked if she stood by her evidence, she responded, "Of course, to my dying day I will stand by every word of my testimony."
Guthrie implied that some public members were "frankly disgusted" by the six-week court proceedings in Fairfax County, Virginia.
Heard response: "Absolutely. I would not fault the average person for viewing this and how it has been reported and concluding that it depicts Hollywood brats at their worst.
"However, what many do not realize is that it is truly far larger than that. This is not merely about our freedom of speech under the First Amendment."
However, Guthrie interrupted: "However, the First Amendment protects freedom of speech. It does not shield defamatory lies, which was the issue in the case at hand."
Heard stated that the "vast majority" of the trial transpired on social media and that it had become "an example of that gone haywire, gone amok."
She recalled arriving daily at the courthouse and stated: "Every day, I passed three, four, and sometimes six city blocks lined with individuals holding posters that read "Burn the witch" and "Death to Amber."
"After three-and-a-half weeks I took the stand and saw a courtroom packed full of Captain Jack Sparrow fans who were vocal, energised." the witness said.
Heard described it as "the most humiliating and horrible thing I have ever been through"
"I have never felt so disconnected from my humanity. I felt beneath human "She stated,
She said, "Even if you think that I'm lying you still couldn't tell me, look me in the eye and tell me that you think on social media there's been a fair representation."
When challenged by the journalist about Depp's assertion in court that he never hit her, Heard answered, "Yes, that is a lie."
Heard also addressed her conduct during the marriage, stating: "Throughout our relationship, I did and spoke awful, regrettable acts and words. I exhibited horrific, almost unrecognizable behavior—so much regret.
"I have freely, publicly, and voluntarily discussed my actions. I debated the foul language and how I was pushed to the point where I did not know the difference between right and wrong.
"Because I was, I will always continue to feel like I was a part of this and the other half of this relationship. And it was ugly but could have been really attractive."
Heard stated that their relationship was "very, very toxic."
She went on: "We were horrible to one another. I committed a multitude of errors, a multitude of errors, and I have always been truthful."
Two weeks ago, a jury determined that Heard's 2018 Washington Post piece about her experiences as a survivor of domestic violence was defamatory.
During his testimony, Depp continually refuted the "outrageous, outlandish" abuse allegations.
The 59-year-old was granted $10.35 million in damages (£8.2 million).
Heard prevailed on one count of her countersuit, arguing that Depp's publicity agency defamed her by suggesting her charges were a #MeToo-inspired "an abuse hoax."
A jury awarded her $2 million in damages (£1.5 million)
Depp had already lost a similar case in the United Kingdom against the publisher of The Sun tabloid for a 2018 piece that referred to him as a "wife-beater."
The interview with Amber Heard airs on Tuesday and Wednesday's editions of the Today program on NBC News, with additional segments appearing on Friday during a particular Dateline program.