US President Donald Trump and his Democratic rival Joe Biden will meet in Cleveland, Ohio on Tuesday for the first Presidential debate.
It had been due to take place at the University of Notre Dame in Indiana but was changed because of concerns over coronavirus precautions.
It will now be co-hosted by Case Western Reserve University and the Cleveland Clinic.
The two men will hold three debates in all before the 3 November vote.
Reverend John I Jenkins, president of Notre Dame in South Bend, Indiana, said the health precautions needed to stage the event "would have greatly diminished the educational value of hosting the debate on our campus".
The new location will be at Western Reserve University's Health Education Campus, the Commission on Presidential Debates said.
The second presidential debate on 15 October will take place in Miami after getting shifted from the University of Michigan.
The third will take place in Nashville on 22 October, while a debate between Vice-President Mike Pence and the Democratic vice-presidential nominee - who has still to be chosen - will be held on 7 October in Salt Lake City.
Source: BBC